Increased peripheral blood CD4+ T cell responses to deamidated but not to native gliadin in children with coeliac disease.

@article{Lammi2012IncreasedPB,
  title={Increased peripheral blood CD4+ T cell responses to deamidated but not to native gliadin in children with coeliac disease.},
  author={Anne Lammi and Pekka M Arikoski and Outi Vaarala and Tuure Kinnunen and Jorma Ilonen},
  journal={Clinical and experimental immunology},
  year={2012},
  volume={168 2},
  pages={207-14}
}
T cell recognition of gliadin from dietary gluten is essential for the pathogenesis of coeliac disease (CD). The aim of the present study was to analyse whether gliadin-specific T cells are detectable in the circulation of children with newly diagnosed coeliac disease by using a sensitive carboxfluorescein diacetate succinimidyl ester (CFSE) dilution method. Peripheral blood CD4(+) T cell responses were analysed in 20 children at diagnosis of CD and compared to those in 64 healthy control… CONTINUE READING

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