Increased peripheral alpha 1-adrenoceptor sensitivity following chronic thioridazine treatment in the pithed rat.

@article{Cuff1989IncreasedPA,
  title={Increased peripheral alpha 1-adrenoceptor sensitivity following chronic thioridazine treatment in the pithed rat.},
  author={M L Cuff{\'i} and Eduardo A. Mart{\'i}nez Vila and A. Bernat Bad{\'i}a},
  journal={European journal of pharmacology},
  year={1989},
  volume={168 1},
  pages={
          111-3
        }
}
The effect of chronic treatment (10 days) with thioridazine (25 mg/kg per day, i.p.) on the increase in diastolic blood pressure induced by methoxamine and xylazine was studied in the pithed rat. The dose-response curve for methoxamine, but not for xylazine, was shifted to the left by the neuroleptic. These results indicate that postjunctional alpha 1-adrenoceptors in the rat blood vessels become supersensitive after long-term treatment with thioridazine. 
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