Increased perfusion and angiogenesis in a hindlimb ischemia model with plasmid FGF-2 delivered by noninvasive electroporation

@article{Ferraro2010IncreasedPA,
  title={Increased perfusion and angiogenesis in a hindlimb ischemia model with plasmid FGF-2 delivered by noninvasive electroporation},
  author={Bernadette Ferraro and Yolmari L. Cruz and Margaret K. Baldwin and Domenico Coppola and Richard Heller},
  journal={Gene Therapy},
  year={2010},
  volume={17},
  pages={763-769}
}
Gene therapy approaches delivering fibroblast growth factor-2 (FGF-2) have shown promise as a potential treatment for increasing blood flow to ischemic limbs. Currently, effective noninvasive techniques to deliver plasmids encoding genes of therapeutic interest, such as FGF-2, are limited. We sought to determine if intradermal injection of plasmid DNA encoding FGF-2 (pFGF) followed by noninvasive cutaneous electroporation (pFGFE+) could increase blood flow and angiogenesis in a rat model of… CONTINUE READING

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