Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats.

@article{Rafacho2008IncreasedPI,
  title={Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats.},
  author={Alex Rafacho and Daniele L Ribeiro and Ant{\^o}nio Carlos Boschero and Sebasti{\~a}o R Taboga and Jos{\'e} Roberto Bosqueiro},
  journal={International journal of experimental pathology},
  year={2008},
  volume={89 4},
  pages={
          264-75
        }
}
It is well known that glucocorticoids induce peripheral insulin resistance in rodents and humans. Here, we investigated the structural and ultrastructural modifications, as well as the proteins involved in beta-cell function and proliferation, in islets from insulin-resistant rats. Adult male Wistar rats were made insulin resistant by daily administration of dexamethasone (DEX; 1mg/kg, i.p.) for five consecutive days, whilst control (CTL) rats received saline alone. Structure analyses showed a… CONTINUE READING
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