Increased pancreatic acinar content and secretion of cationic trypsinogen following 30-day continuous ethanol intoxication in rats.

@article{Tsukamoto1986IncreasedPA,
  title={Increased pancreatic acinar content and secretion of cationic trypsinogen following 30-day continuous ethanol intoxication in rats.},
  author={Hidekazu Tsukamoto and Hariharan Sankaran and G. Y. S{\'a}nchez Delgado and Roger D Reidelberger and Clifford W. Deveney and Corey Largman},
  journal={Biochemical pharmacology},
  year={1986},
  volume={35 20},
  pages={3623-9}
}
The effects of sustained, high blood alcohol levels (216 +/- 120 mg/100 ml, S.D.) for 30 days on cholecystokinin (CCK)-mediated pancreatic exocrine function were studied in a rat model that achieves both maximally controlled, optimal nutrition and high alcohol intake (approximately 40.5% of total calories). In alcohol-fed rats, basal plasma levels of immunoreactive cationic trypsinogen (ICT) were reduced by 50% (P less than 0.05), but intravenous doses (0-30 IDU/kg/hr; 1 IDU = approximately 62… CONTINUE READING

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