Increased p16 levels correlate with pRb alterations in human urothelial cells.

@article{Yeager1995IncreasedPL,
  title={Increased p16 levels correlate with pRb alterations in human urothelial cells.},
  author={Thomas R Yeager and Walter M. Stadler and Cassandra D. Belair and Jairaj Puthenveettil and Olofunmilayo I. Olopade and Catherine A. Reznikoff},
  journal={Cancer research},
  year={1995},
  volume={55 3},
  pages={493-7}
}
The CDKN2 (MTS1) gene is located at 9p21; its product, p16, inhibits the cyclin D/CDK4 complex that phosphorylates pRb, thus negatively regulating cell cycle progression [M. Serrano et al., Nature (Lond.), 366: 704, 1994; A. Kamb et al., Science (Washington DC), 264: 436, 1994; T. Nobori et al., Nature (Lond.), 368: 753, 1994]. CDKN2 mutations are more common in cultured human uroepithelial cells (HUC) than in uncultured bladder cancers. We examined the status of CDKN2/p16 in early and late… CONTINUE READING