Increased oxysterol contents in diabetic rat hearts: their involvement in diabetic cardiomyopathy.

@article{Matsui1997IncreasedOC,
  title={Increased oxysterol contents in diabetic rat hearts: their involvement in diabetic cardiomyopathy.},
  author={Hideo Matsui and Kenji Okumura and Hiroshi Mukawa and Makoto Hibino and Yukio Toki and Takayuki Ito},
  journal={The Canadian journal of cardiology},
  year={1997},
  volume={13 4},
  pages={
          373-9
        }
}
BACKGROUND Abnormal lipid metabolism associated with diabetes mellitus has been proposed to be involved in the pathogenesis of diabetic cardiomyopathy. Oxysterols, oxidation derivatives of cholesterol, are known to be highly cytotoxic. OBJECTIVE To monitor changes in myocardial oxysterols and to assess the effect of probucol, a lipid lowering agent, on myocardial lipids and oxysterols in diabetic rats. METHODS AND RESULTS Streptozotocin-induced diabetic rats were divided into two groups… CONTINUE READING

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