Increased oxidizability of low-density lipoproteins in hypothyroidism.

  title={Increased oxidizability of low-density lipoproteins in hypothyroidism.},
  author={Theo Diekman and Pierre N. M. Demacker and John J. P. Kastelein and Anton F. H. Stalenhoef and Wilmar Maarten Wiersinga},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={83 5},
Hypothyroidism leads to an increase of plasma low-density lipoprotein (LDL) cholesterol levels. Oxidation of LDL particles changes their intrinsic properties, thereby enhancing the development of atherosclerosis. T4 has three specific binding sites on apolipoprotein B; furthermore it inhibits LDL oxidation in vitro. We therefore hypothesized that T4… CONTINUE READING