Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes.

Abstract

OBJECTIVE AND METHOD There is a growing amount of data indicating that alterations in brain-derived neurotrophic factor and increased oxidative stress may play a role in the pathophysiology of bipolar disorder. In light of recent evidence demonstrating that brain-derived neurotrophic factor levels are decreased in situations of increased oxidative stress… (More)

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