Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease

  title={Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease},
  author={Lisa Lih-Brody and Saul R. Powell and Kevin P. Collier and G. Mallikarjun Reddy and MS ReneeCerchia and Ellen Kahn and Gary S. Weissman and S. Katz and Robert A. Floyd and Matthew McKinley and Stanley E. Fisher and Gerard Mullin},
  journal={Digestive Diseases and Sciences},
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation whose cellular components are capable of oxidative respiratory bursts that may result in tissue injury. Mucosal biopsies were analyzed for protein carbonyl content (POPs), DNA oxidation products [8-hydroxy-2′-deoxyguanosine (8-OHdG)], reactive oxygen intermediates (ROIs), trace metals (copper, zinc, and iron) and superoxide dismutase (Cu-Zn SOD). In Crohn's disease biopsies, there was an increase in ROIs, POPs… CONTINUE READING
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