Increased oxidative metabolism is associated with erythroid precursor expansion in β0-thalassaemia/Hb E disease.

Abstract

Erythropoiesis in β0-thalassaemia/Hb E patients, the most common variant form of β-thalassaemia in Southeast Asia, is characterized by accelerated differentiation and over-expansion of erythroid precursor cells. The mechanism driving this accelerated expansion and differentiation remain unknown. To address this issue a proteomic analysis was undertaken to… (More)
DOI: 10.1016/j.bcmd.2011.06.005

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