Increased oxidative metabolism in PMA-activated lymphocytes: a flow cytometric study.

@article{Rabesandratana1992IncreasedOM,
  title={Increased oxidative metabolism in PMA-activated lymphocytes: a flow cytometric study.},
  author={Herisoa Rabesandratana and Arthur M. Fournier and M T Ch{\^a}teau and Ang{\'e}line C Serre and Jacques Dornand},
  journal={International journal of immunopharmacology},
  year={1992},
  volume={14 5},
  pages={895-902}
}
Flow cytometry and the fluorescent dyes DCF and R123 were used to examine oxygen metabolite production in human leukocytes and T-lymphoblastoid Jurkat cells, activated by PMA or by FMLP. When unseparated leukocytes were activated by PMA, oxidative products were generated not only in PMN and monocytes but also to a lower extent in lymphocytes. These responses were correlated with protein kinase C activation. PMA did not, however, induce the synthesis of reactive oxygen species in isolated… CONTINUE READING