Increased oxidative damage to DNA in an animal model of amyotrophic lateral sclerosis.

@article{Aguirre2005IncreasedOD,
  title={Increased oxidative damage to DNA in an animal model of amyotrophic lateral sclerosis.},
  author={Norberto Aguirre and Myron Flint Beal and Wayne R. Matson and Mikhail B. Bogdanov},
  journal={Free radical research},
  year={2005},
  volume={39 4},
  pages={383-8}
}
Substantial evidence suggest that oxidative damage may play a role in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). We examined levels of 8-Hydroxy-2'-deoxyguanosine (8OH2'dG) in the nuclear DNA from the spinal cord, frontal cortex, striatum and cerebellum from G93A mice at 60, 90, and 120 days of age. We also used in vivo microdialysis to… CONTINUE READING