Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation

@article{Giuliani2012IncreasedOD,
  title={Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation},
  author={Nicola Giuliani and Mark J. Ferretti and Marina Bolzoni and Paola Storti and Mirca Lazzaretti and Benedetta Dalla Palma and Sabrina Bonomini and Eugenia Marta Martella and Luca Agnelli and Antonino Neri and Francesca Ceccarelli and Carla Palumbo},
  journal={Leukemia},
  year={2012},
  volume={26},
  pages={1391-1401}
}
The involvement of osteocytes in multiple myeloma (MM)-induced osteoclast (OCL) formation and bone lesions is still unknown. Osteocytes regulate bone remodelling at least partially, as a result of their cell death triggering OCL recruitment. In this study, we found that the number of viable osteocytes was significantly smaller in MM patients than in healthy controls, and negatively correlated with the number of OCLs. Moreover, the MM patients with bone lesions had a significantly smaller number… CONTINUE READING
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References

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SHOWING 1-10 OF 66 REFERENCES

The role of osteocyte apoptosis in cancer chemotherapy - induced bone loss

  • SA Al-Dujaili, E Lau, H Al-Dujaili, K Tsang, A Guenther, L You
  • J Cell Physiol
  • 2011

e-pub ahead of print 1 October

  • T Shandala, YS Ng, B Hopwood, YC Yip, BK Foster, CJ. Xian
  • Bone
  • 2011

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