Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.

@article{Ruberte2004IncreasedOL,
  title={Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.},
  author={Jes{\'u}s Ruberte and Eduard Ayuso and Marc Navarro and Ana G. Carretero and V{\'i}ctor Nacher and Virginia Haurigot and M{\'o}nica George and Cristina Llombart and Alba Casellas and Cristina Tom{\'a}s da Costa and Assumpci{\'o} Bosch and Fatima Bosch},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 8},
  pages={1149-57}
}
IGF-1 has been associated with the pathogenesis of diabetic retinopathy, although its role is not fully understood. Here we show that normoglycemic/normoinsulinemic transgenic mice overexpressing IGF-1 in the retina developed most alterations seen in human diabetic eye disease. A paracrine effect of IGF-1 in the retina initiated vascular alterations that progressed from nonproliferative to proliferative retinopathy and retinal detachment. Eyes from 2-month-old transgenic mice showed loss of… CONTINUE READING