Increased numbers of CD5+ B cells and T cell receptor (TCR) gamma delta+ T cells are associated with younger age of onset in rheumatoid arthritis (RA).

@article{Hassan1996IncreasedNO,
  title={Increased numbers of CD5+ B cells and T cell receptor (TCR) gamma delta+ T cells are associated with younger age of onset in rheumatoid arthritis (RA).},
  author={Jaythoon Hassan and Ghada Yanni and V Hegarty and Conleth Feighery and Barry Bresnihan and Alex Whelan},
  journal={Clinical and experimental immunology},
  year={1996},
  volume={103 3},
  pages={353-6}
}
Patients presenting with RA before the age of 45 years (younger onset) are known to have more aggressive disease compared with patients presenting after the age of 65 years (older onset). Coordinated expansion of circulating CD5+ B cell and TCR gamma delta+ T cell levels has been reported in patients with RA. This study assesses the peripheral blood levels of these two cell types in RA patients with younger and older onset of disease. CD5+ B cell levels were significantly elevated in the… CONTINUE READING