Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice.

@article{Tasan2009IncreasedNM,
  title={Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice.},
  author={Ramon O Tasan and S Lin and Alfred Hetzenauer and Nicolas Singewald and Herbert Herzog and G{\"u}nther Sperk},
  journal={Neuroscience},
  year={2009},
  volume={158 4},
  pages={1717-30}
}
There is growing evidence that neuropeptide Y (NPY) acting through Y1 and Y2 receptors has a prominent role in modulating anxiety- and depression-like behavior in rodents. However, a role of other Y-receptors like that of Y4 receptors in this process is poorly understood. We now investigated male Y2, Y4 single and Y2/Y4 double knockout mice in behavioral paradigms for changes in motor activity, anxiety and depression-like behavior. Motor activity was increased in Y2, Y4 and Y2/Y4 knockout mice… CONTINUE READING
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