Increased norepinephrine release during sympathetic nerve stimulation and its inhibition by adenosine in the isolated perfused kidney of spontaneously hypertensive rats.

@article{Ekas1983IncreasedNR,
  title={Increased norepinephrine release during sympathetic nerve stimulation and its inhibition by adenosine in the isolated perfused kidney of spontaneously hypertensive rats.},
  author={R D Ekas and Marie L. Steenberg and Mustafa F. Lokhandwala},
  journal={Clinical and experimental hypertension. Part A, Theory and practice},
  year={1983},
  volume={5 1},
  pages={41-8}
}
The present study was performed to measure norepinephrine release during sympathetic nerve stimulation and determine the inhibitory action of adenosine on stimulus-induced release of norepinephrine in the isolated perfused kidney of WKY and SHR. Norepinephrine release during periarterial nerve stimulation was measured as total 3H-overflow since greater than 75% of total 3H-overflow was 3H-norepinephrine in both the WKY and SHR. A significantly greater increase in 3H-norepinephrine overflow was… CONTINUE READING