Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder.

@article{Kluge2007IncreasedNS,
  title={Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder.},
  author={Michael Kluge and Petra Schuessler and Heike E. Kuenzel and Martin Dresler and A. Yassouridis and Axel Steiger},
  journal={Journal of psychiatric research},
  year={2007},
  volume={41 11},
  pages={928-33}
}
Information on the function of the hypothalamic-pituitary-adrenal (HPA) axis, the main mammalian system of stress response, in obsessive compulsive disorder (OCD) is inconsistent. In this study, nine inpatients with a DSM-IV diagnosis of OCD without comorbid major depression (Yale-Brown Obsessive Compulsive Scale [Y-BOCS] score >15; HAMD-21 total score 16) and nine healthy matched controls were included. Blood of patients (seven males; 31.8 +/- 9.3 years, Y-BOCS: 27.3 +/- 4.3, HAMD-21: 13.3… CONTINUE READING