Increased nociceptive response in mice lacking the adenosine A1 receptor.

@article{Wu2005IncreasedNR,
  title={Increased nociceptive response in mice lacking the adenosine A1 receptor.},
  author={Wei-Ping Wu and J -X. Hao and Linda Halldner and Cecilia L{\"o}vdahl and Gary E Delander and Zsuzsanna Wiesenfeld-Hallin and Bertil B. Fredholm and Xiao-Jun Xu},
  journal={Pain},
  year={2005},
  volume={113 3},
  pages={395-404}
}
The role of the adenosine A1 receptor in nociception was assessed using mice lacking the A1 receptor (A1R-/-) and in rats. Under normal conditions, the A1R-/- mice exhibited moderate heat hyperalgesia in comparison to the wild-type mice (A1R+/+). The mechanical and cold sensitivity were unchanged. The antinociceptive effect of morphine given intrathecally (i.t.), but not systemically, was reduced in A1R-/- mice and this reduction in the spinal effect of morphine was not associated with a… CONTINUE READING

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