Increased nitroglycerin-induced relaxation by genistein in rat aortic rings.

@article{Satake1999IncreasedNR,
  title={Increased nitroglycerin-induced relaxation by genistein in rat aortic rings.},
  author={N. Satake and M. Imanishi and S. Shibata},
  journal={European journal of pharmacology},
  year={1999},
  volume={377 2-3},
  pages={
          193-7
        }
}
The effect of genistein, a tyrosine kinase inhibitor, on nitroglycerin-induced relaxation was examined in rat aortic rings contracted by phenylephrine. In rat aortic rings, genistein (10(-5) M and 3x10(-5) M), a tyrosine kinase inhibitor, but not daidzein, an analogue of genistein, increased relaxation induced by nitroglycerin in a concentration-dependent manner. Iberiotoxin, an inhibitor of Ca2+ -activated K+ channels, inhibited the relaxation induced by nitroglycerin, but it did not affect… Expand
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