Increased neutralization sensitivity of recently emerged CXCR4-using human immunodeficiency virus type 1 strains compared to coexisting CCR5-using variants from the same patient.

@article{Bunnik2007IncreasedNS,
  title={Increased neutralization sensitivity of recently emerged CXCR4-using human immunodeficiency virus type 1 strains compared to coexisting CCR5-using variants from the same patient.},
  author={Evelien M. Bunnik and Esther D. Quakkelaar and Ad van Nuenen and Brigitte D M Boeser-Nunnink and Hanneke Schuitemaker},
  journal={Journal of virology},
  year={2007},
  volume={81 2},
  pages={
          525-31
        }
}
CXCR4-using (X4) human immunodeficiency virus type 1 (HIV-1) variants evolve from CCR5-using (R5) variants relatively late in the natural course of infection in 50% of HIV-1 subtype B-infected individuals and subsequently coexist with R5 HIV-1 variants. This relatively late appearance of X4 HIV-1 variants is poorly understood. Here we tested the neutralization sensitivity for soluble CD4 (sCD4) and the broadly neutralizing antibodies IgG1b12, 2F5, 4E10, and 2G12 of multiple coexisting clonal R5… CONTINUE READING
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