Increased neutralization sensitivity and reduced replicative capacity of human immunodeficiency virus type 1 after short-term in vivo or in vitro passage through chimpanzees.

@article{Beaumont2000IncreasedNS,
  title={Increased neutralization sensitivity and reduced replicative capacity of human immunodeficiency virus type 1 after short-term in vivo or in vitro passage through chimpanzees.},
  author={T. Beaumont and Sophie FM Broersen and Ad van Nuenen and Han G. Huisman and A M de Roda Husman and Jonathan Luke Heeney and Hanneke Schuitemaker},
  journal={Journal of virology},
  year={2000},
  volume={74 17},
  pages={7699-707}
}
Development of disease is extremely rare in chimpanzees when inoculated with either T-cell-line-adapted neutralization-sensitive or primary human immunodeficiency virus type 1 (HIV-1), at first excluding a role for HIV-1 neutralization sensitivity in the clinical course of infection. Interestingly, we observed that short-term in vivo and in vitro passage of… CONTINUE READING