Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome

@article{Evans1985IncreasedNA,
  title={Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome},
  author={Dr Imogen M. A. Evans and Glynis Dunn and Philip D. Minor and Geoffrey C. Schild and Alan J. Cann and Glyn Stanway and Jeffrey W. Almond and Kathleen M. Currey and Jacob V. Maizel},
  journal={Nature},
  year={1985},
  volume={314},
  pages={548-550}
}
Most of the small number of cases of poliomyelitis which occur in countries where Sabin's attenuated poliovirus vaccines are used are temporally associated with administration of vaccine and involve polioviruses of types 2 and 3 (ref. 1). Recent studies have provided convincing evidence that the Sabin type 2 and 3 viruses themselves may revert to a neurovirulent phenotype on passage in man2–6. We report here that a point mutation in the 5′ noncoding region of the genome of the poliovirus type 3… CONTINUE READING

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