Increased neurogenesis after experimental Streptococcus pneumoniae meningitis.

  title={Increased neurogenesis after experimental Streptococcus pneumoniae meningitis.},
  author={Joachim Gerber and Tobias Boettcher and Judith Bering and Stephanie Bunkowski and Wolfgang Br{\"u}ck and Ulrich Kuhnt and Roland Nau},
  journal={Journal of neuroscience research},
  volume={73 4},
Neuronal damage in the hippocampal formation is a common feature in animal models of bacterial meningitis and human disease. In mouse and rabbit models of Streptococcus pneumoniae meningitis, proliferation of neural progenitor cells quantified by bromodeoxyuridine (BrdU) incorporation was enhanced in the subgranular layer of the dentate gyrus. In mice, the density of BrdU-labeled cells was maximal on Day 2 after infection. Approximately 60% of the cells labeled by BrdU between Days 7 and 10… CONTINUE READING