Increased neuroendocrine reactivity and decreased brain mineralocorticoid receptor-binding capacity in aged dogs.

@article{Rothuizen1993IncreasedNR,
  title={Increased neuroendocrine reactivity and decreased brain mineralocorticoid receptor-binding capacity in aged dogs.},
  author={Jan Rothuizen and Johannes M H M Reul and Frederik J van Sluijs and Jan A. Mol and Ad Rijnberk and Edo Ronald de Kloet},
  journal={Endocrinology},
  year={1993},
  volume={132 1},
  pages={161-8}
}
The effects of aging on the regulation of the hypothalamus-pituitary-adrenocortical (HPA) system of the dog were investigated. For this purpose, we compared 11 healthy dogs, 11-14 yr old, with 14 young mature dogs, 18-24 months of age. Significantly higher basal HPA activity in the old dogs was indicated by their higher resting plasma concentrations of ACTH, alpha MSH, and cortisol over a 6-week period and higher cortisol excretion in 24-h urine. After stress by immobilization as well as by… CONTINUE READING

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