Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesia

@article{Banik2005IncreasedNG,
  title={Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesia},
  author={Ratan K Banik and Alberto R. Subieta and Chaoran Wu and Timothy J. Brennan},
  journal={Pain},
  year={2005},
  volume={117},
  pages={68-76}
}
Acutely, nerve growth factor (NGF) exerts profound effects on nociceptive transmission and produces pain and hyperalgesia. In the present study, we sought to determine the tissue levels and role of NGF after a plantar incision. A substantial increase in NGF protein expression occurred in skin 4-h, 1-day and 2-days and 5-days after incision comparing contralateral uninjured skin. Plantar incision did not change NGF levels in the tibial nerve and L4-L6 dorsal root ganglia. The therapeutic effect… CONTINUE READING

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