Increased negative impact of donor HLA-specific together with non-HLA-specific antibodies on graft outcome.

@article{Reinsmoen2014IncreasedNI,
  title={Increased negative impact of donor HLA-specific together with non-HLA-specific antibodies on graft outcome.},
  author={Nancy L. Reinsmoen and Chih-Hung Lai and J Mirocha and Kai Cao and Geraldine Ong and Mehrnoush Naim and Qi Wang and Mark Haas and Matthew Rafiei and Lawrence Czer and Jignesh L. Patel and Jon Kobashigawa},
  journal={Transplantation},
  year={2014},
  volume={97 5},
  pages={595-601}
}
BACKGROUND De novo donor HLA-specific (dnDSA) and non-HLA antibodies including antiangiotensin type 1 receptor antibodies (AT1R-abs) have been associated with antibody-mediated rejection (AMR) and decreased graft survival as well as cellular-mediated rejection (CMR) and early onset of microvasculopathy in heart transplantation. The aim of our study was to determine the impact of anti-AT1R-ab and anti-donor HLA-specific antibody (DSA) on clinical outcomes. METHODS Pretransplant and… CONTINUE READING
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