Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins.

@article{Witkiewicz2010IncreasedNK,
  title={Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins.},
  author={Agnieszka K. Witkiewicz and Thomas S. McConnell and Magdalena Potoczek and Robert V.B. Emmons and Robert J. Kurman},
  journal={Human pathology},
  year={2010},
  volume={41 1},
  pages={
          26-32
        }
}
Progestins are used to treat complex atypical hyperplasia and well-differentiated endometrial carcinoma in women who desire fertility preservation and those who are poor surgical candidates. Although sensitivity to progestins is thought to be associated with the presence of estrogen and progesterone receptors, it is known that receptor-negative tumors can also respond to the agent, suggesting that there is another direct antitumor action of progestin. Because tumor immune response is an… CONTINUE READING

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