Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy.

@article{Christoffersen2006IncreasedNP,
  title={Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy.},
  author={Tue E. H. Christoffersen and Mark Aplin and Claes C Strom and Soren P Sheikh and Ole Skott and Peter K. Busk and Stig Haunso and Lars Bo Nielsen},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={290 4},
  pages={H1635-41}
}
Both atrial (ANP) and brain (BNP) natriuretic peptide affect development of cardiac hypertrophy and fibrosis via binding to natriuretic peptide receptor (NPR)-A in the heart. A putative clearance receptor, NPR-C, is believed to regulate cardiac levels of ANP and BNP. The renin-angiotensin system also affects cardiac hypertrophy and fibrosis. In this study we examined the expression of genes for the NPRs in rats with pressure-overload cardiac hypertrophy. The ANG II type 1 receptor was blocked… CONTINUE READING

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