Increased myofibrillar protein phosphatase-1 activity impairs rat aortic smooth muscle activation after hypoxia.

@article{Teoh2003IncreasedMP,
  title={Increased myofibrillar protein phosphatase-1 activity impairs rat aortic smooth muscle activation after hypoxia.},
  author={Hockluen Teoh and Mary E. Zacour and Avraham Dov Wener and Lakshman Gunaratnam and Michael P Ward},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 4},
  pages={
          H1182-9
        }
}
We hypothesized that increased myofibrillar type 1 protein phosphatase (PP1) catalytic activity contributes to impaired aortic smooth muscle contraction after hypoxia. Our results show that inhibition of PP1 activity with microcystin-LR (50 nmol/l) or okadaic acid (100 nmol/l) increased phenylephrine- and KCl-induced contraction to a greater extent in aortic rings from rats exposed to hypoxia (10% O(2)) for 48 h than in rings from normoxic animals. PP1 inhibition also restored the level of… CONTINUE READING

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