Increased myocardial GRP94 amounts during sustained atrial fibrillation: a protective response?

@article{Vitadello2001IncreasedMG,
  title={Increased myocardial GRP94 amounts during sustained atrial fibrillation: a protective response?},
  author={Maurizio Vitadello and Jannie Ausma and Marcel Borgers and Alfonso Gambino and Dino Casarotto and Luisa Gorza},
  journal={Circulation},
  year={2001},
  volume={103 17},
  pages={2201-6}
}
BACKGROUND Structural and phenotypic changes of cardiomyocytes characterize atrial fibrillation. We investigated whether changes in the glucose-regulated protein GRP94, which is essential for cell viability, occur in the presence of chronic atrial fibrillation. METHODS AND RESULTS Samples of fibrillating atrial myocardium obtained from both goat and human hearts were analyzed for GRP94 expression by an immunologic approach. In goats, atrial fibrillation was induced and maintained for 2, 4, 8… CONTINUE READING

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Reduced amount of the glucose-regulated protein GRP94 in skeletal myoblasts results in loss of fusion competence.

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