Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis.

@article{Wynn2007IncreasedMA,
  title={Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis.},
  author={James L Wynn and Philip O Scumpia and Matthew J. Delano and Kerri A. O'Malley and Ricardo F Ungaro and Amer S. Abouhamze and Lyle L. Moldawer},
  journal={Shock},
  year={2007},
  volume={28 6},
  pages={675-683}
}
Neonates have a higher prevalence of bacterial sepsis and have greater morbidity and mortality from sepsis than other infants and children. Our understanding of the inflammatory and immunological responses to sepsis is hampered by the lack of appropriate neonatal murine models. In the present report, we have developed a cecal slurry model of generalized peritonitis in neonatal mice (age range, 5-7 days) and compared the outcome and the innate and adaptive cellular responses of these animals… CONTINUE READING

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