Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress

@article{Knupp2018IncreasedMR,
  title={Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress},
  author={Jeffrey Knupp and Peter Arvan and Amy M. Chang},
  journal={Cell Death & Differentiation},
  year={2018},
  pages={1-15}
}
Protein misfolding in the endoplasmic reticulum (ER) is accompanied by adaptive cellular responses to promote cell survival. We now show that activation of mitochondrial respiration is a critical component of an adaptive ER stress response, requiring the unfolded protein response (UPR) sensor Ire1, and also calcium signaling via calcineurin. In yeast and mammalian cells lacking Ire1 or calcineurin, respiratory activation is impaired in response to ER stress; accumulation of mitochondrial… CONTINUE READING
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