Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase.

@article{Hollenberg2000IncreasedMR,
  title={Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase.},
  author={Steven M. Hollenberg and Marsha Broussard and Joseph M. Osman and Jospeh E. Parrillo},
  journal={Circulation research},
  year={2000},
  volume={86 7},
  pages={774-8}
}
Persistent vasodilation characteristic of septic shock may result from overproduction of nitric oxide and can lead to pressor-refractory hypotension and death. To evaluate the significance of cytokine-inducible nitric oxide synthase (iNOS) in the pathogenesis of sepsis, we used a clinically relevant mouse model of sepsis and compared mortality and microvascular reactivity in wild-type (WT) mice and transgenic mice deficient in iNOS. WT C57BL/6 and iNOS-deficient mice were made septic by cecal… CONTINUE READING

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