Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor.

@article{Roberts1995IncreasedMP,
  title={Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor.},
  author={Walter Gregory Roberts and George E. Palade},
  journal={Journal of cell science},
  year={1995},
  volume={108 ( Pt 6)},
  pages={2369-79}
}
The vascular endothelial growth factor (VEGF) was originally described as vascular permeability factor due to its ability to increase microvascular permeability to plasma proteins. However, the vessel types (arteriolar, venular, and capillary) affected by VEGF and the modification of endothelial morphology in response to increased permeability induced by VEGF in vivo have not been precisely documented. By topical application or intradermal injection of recombinant human VEGF-165 we find that… CONTINUE READING