Increased microsatellite instability and epigenetic inactivation of the hMLH1 gene in head and neck squamous cell carcinoma.

@article{Zuo2009IncreasedMI,
  title={Increased microsatellite instability and epigenetic inactivation of the hMLH1 gene in head and neck squamous cell carcinoma.},
  author={Chunlai Zuo and Haihong Zhang and Horace J. Spencer and Emre A Vural and James Y. Suen and Steven A. Schichman and Bruce Robert Smoller and Mimi S. Kokoska and Chun-Yang Fan},
  journal={Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery},
  year={2009},
  volume={141 4},
  pages={484-90}
}
OBJECTIVE The study is designed to elucidate the relationship between epigenetic silencing of the hMLH1 (human MutL homologue 1) gene and microsatellite instability (MSI) and the prognostic values of hMLH1 promoter methylation and MSI in head and neck squamous cell carcinoma (HNSCC). STUDY DESIGN Cross-sectional study. SETTING Tertiary referral center. SUBJECTS AND METHODS A total of 120 cases of HNSCC were analyzed for hMLH1 promoter hypermethylation, protein expression, and MSI by using… CONTINUE READING

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