Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage.

@article{Kuwabara2011IncreasedMA,
  title={Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage.},
  author={Yasuhide Kuwabara and Koh Ono and Takahiro Horie and Hitoo Nishi and Kazuya Nagao and M. Kinoshita and Shin Watanabe and Osamu Baba and Yoji Kojima and Satoshi Shizuta and Masao Imai and Toshihiro Tamura and Toru Kita and Takeshi Kimura},
  journal={Circulation. Cardiovascular genetics},
  year={2011},
  volume={4 4},
  pages={446-54}
}
BACKGROUND Recently, elevation of circulating muscle-specific microRNA (miRNA) levels has been reported in patients with acute myocardial infarction. However, it is still unclear from which part of the myocardium or under what conditions miRNAs are released into circulating blood. The purpose of this study was to identify the source of elevated levels of circulating miRNAs and their function in cardiovascular diseases. METHODS AND RESULTS Serum levels of miRNA (miR)-1 and miR-133a were… CONTINUE READING
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