Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats.

@article{Wang2004IncreasedMA,
  title={Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats.},
  author={Xiaoxia Wang and Kaushik Desai and Jes Thorn Clausen and Ling-Yun Wu},
  journal={Kidney international},
  year={2004},
  volume={66 6},
  pages={2315-21}
}
BACKGROUND Methylglyoxal (MG), a metabolite of glucose, causes nonenzymatic glycation of proteins to form irreversible advanced glycation end products (AGEs). The role of MG in the development of essential hypertension is unknown, although MG has been extensively studied in relation to diabetes. METHODS Blood pressure of spontaneously hypertensive rats (SHR) and paired Wistar Kyoto (WKY) rats was measured at 5, 8, 13, and 20 weeks of age. HPLC was used to determine the levels of plasma and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…