Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma

@article{Perroud2011IncreasedMO,
  title={Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma},
  author={Nader Perroud and Ariane Paoloni-Giacobino and Paco Prada and Emilie Olié and Annick Salzmann and Rosetta Nicastro and S{\'e}bastien Guillaume and Dominique Mouthon and Christelle Stouder and Karen Dieben and Philippe Huguelet and Philippe Courtet and Alain Malafosse},
  journal={Translational Psychiatry},
  year={2011},
  volume={1}
}
Childhood maltreatment, through epigenetic modification of the glucocorticoid receptor gene (NR3C1), influences the hypothalamic–pituitary–adrenal axis (HPA axis). We investigated whether childhood maltreatment and its severity were associated with increased methylation of the exon 1F NR3C1 promoter, in 101 borderline personality disorder (BPD) and 99 major depressive disorder (MDD) subjects with, respectively, a high and low rate of childhood maltreatment, and 15 MDD subjects with comorbid… Expand
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TLDR
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