Increased methylation of Human Papillomavirus type 16 DNA correlates with viral integration in Vulval Intraepithelial Neoplasia.

@article{Bryant2014IncreasedMO,
  title={Increased methylation of Human Papillomavirus type 16 DNA correlates with viral integration in Vulval Intraepithelial Neoplasia.},
  author={Dean Bryant and Tiffany Onions and Rachel Raybould and Sadie E F Jones and Amanda J Tristram and Samantha J Hibbitts and Alison Nina Fiander and Ned G Powell},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2014},
  volume={61 3},
  pages={393-9}
}
BACKGROUND Methylation of HPV16 DNA is a promising biomarker for triage of HPV positive cervical screening samples but the biological basis for the association between HPV-associated neoplasia and increased methylation is unclear. OBJECTIVES To determine whether HPV16 DNA methylation was associated with viral integration, and investigate the relationships between viral DNA methylation, integration and gene expression. STUDY DESIGN HPV16 DNA methylation, integration and gene expression were… CONTINUE READING
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