Increased medial thalamic choline found in pediatric patients with obsessive-compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study.

@article{Smith2003IncreasedMT,
  title={Increased medial thalamic choline found in pediatric patients with obsessive-compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study.},
  author={Ethan A. Smith and Aileen Russell and Elisa Lorch and Shailesh P. Banerjee and Michelle Rose and Jennifer Ivey and Rashmi P Bhandari and Gregory J. Moore and David R. Rosenberg},
  journal={Biological psychiatry},
  year={2003},
  volume={54 12},
  pages={1399-405}
}
BACKGROUND Neurobiologic abnormalities in medial thalamus have been implicated in the pathogenesis of obsessive-compulsive disorder (OCD). We previously used multislice proton magnetic resonance spectroscopic imaging (1-H MRSI) to identify localized functional neurochemical marker alterations in choline (Cho) in medial but not lateral thalamus in treatment-naïve pediatric patients with OCD compared with matched control subjects. Altered brain Cho levels have also been implicated in the… CONTINUE READING

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