Increased matrix metalloproteinase activity and reduced tissue inhibitor of metalloproteinases-1 levels in amniotic fluids from pregnancies complicated by premature rupture of membranes.

@article{VadilloOrtega1996IncreasedMM,
  title={Increased matrix metalloproteinase activity and reduced tissue inhibitor of metalloproteinases-1 levels in amniotic fluids from pregnancies complicated by premature rupture of membranes.},
  author={Felipe Vadillo-Ortega and Antonio Hern{\'a}ndez and Georgina Gonz{\'a}lez-{\'A}vila and Lilian Bermejo and Kazushi Iwata and Jerome F Strauss},
  journal={American journal of obstetrics and gynecology},
  year={1996},
  volume={174 4},
  pages={1371-6}
}
OBJECTIVES It has been suggested that increased matrix metalloproteinases activity promotes the weakening of the amniochorion during normal and premature rupture of membranes. This study was designed to determine whether levels of matrix metalloproteinases and the tissue inhibitor of metalloproteinases-1 in amniotic fluid change in a pattern consistent with this hypothesis. STUDY DESIGN Gelatinolytic activity, measured by a soluble substrate assay and zymography, and the concentrations of… CONTINUE READING

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