Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma

  title={Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma},
  author={Sumana Mukherjee and Mark J. Roth and Sanford M. Dawsey and Wusheng Yan and Jaime Rodriguez-Canales and Heidi S. Erickson and N. N. Hu and Alisa M Goldstein and Philip R. Taylor and Annely M Richardson and Michael A. Tangrea and Rodrigo F. Chuaqui and Michael R. Emmert-Buck},
  booktitle={Journal of Translational Medicine},
Esophageal squamous cell carcinomas (ESCC) are usually asymptomatic and go undetected until they are incurable. Cytological screening is one strategy to detect ESCC at an early stage and has shown promise in previous studies, although improvement in sensitivity and specificity are needed. Proteases modulate cancer progression by facilitating tumor invasion and metastasis. In the current study, matrix metalloproteinases (MMPs) were studied in a search for new early detection markers for ESCC… CONTINUE READING


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