Increased matrix metalloproteinase-9 with elastolysis in nocturnal asthma.

@article{Pham2003IncreasedMM,
  title={Increased matrix metalloproteinase-9 with elastolysis in nocturnal asthma.},
  author={David N. Pham and Hong Wei Chu and Richard J. Martin and Monica Kraft},
  journal={Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology},
  year={2003},
  volume={90 1},
  pages={72-8}
}
BACKGROUND Matrix metalloproteinase-9 (MMP-9) is capable of degrading elastin, whereas tissue inhibitor of metalloproteinase-1 (TIMP-1) can inhibit MMP-9 activity. We observed reduced airway tissue elastin volume density in six subjects with nocturnal asthma (NA) as compared with seven subjects with nonnocturnal asthma (NNA) and seven normal controls (NL) when endobronchial biopsies were evaluated morphometrically at 4:00 PM and 4:00 AM. OBJECTIVE We hypothesized that increased… CONTINUE READING
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