Increased maternofetal calcium flux in parathyroid hormone-related protein-null mice

@article{Bond2008IncreasedMC,
  title={Increased maternofetal calcium flux in parathyroid hormone-related protein-null mice},
  author={Helen Bond and Mark Robert Dilworth and B Baker and E C Cowley and A Requena Jimenez and Robert D H Boyd and Syed Mazher Husain and Bridget Ward and Colin P Sibley and Jocelyn D Glazier},
  journal={The Journal of Physiology},
  year={2008},
  volume={586},
  pages={2015 - 2025}
}
The role of parathyroid hormone-related protein (PTHrP) in fetal calcium homeostasis and placental calcium transport was examined in mice homozygous for the deletion of the PTHrP gene (PTHrP-/- null; NL) compared to PTHrP+/+ (wild-type; WT) and PTHrP+/- (heterozygous; HZ) littermates. Fetal blood ionized calcium was significantly reduced in NL fetuses compared to WT and HZ groups at 18 days of pregnancy (dp) with abolition of the fetomaternal calcium gradient. In situ placental perfusion of the… CONTINUE READING
14 Extracted Citations
43 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 14 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 43 references

Placental transfer

  • DE Atkinson, RDH Boyd, CP Sibley
  • Knobil and Neill’s Physiology of Reproduction,
  • 2006
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…