Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1

@article{Plymate2003IncreasedMS,
  title={Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1},
  author={Stephen R. Plymate and Kathy H Haugk and Cynthia C. T. Sprenger and Peter S. Nelson and Marie K Tennant and Yuping Zhang and Larry W. Oberley and Weixiong Zhong and Rolf H Drivdahl and Terry D. Oberley},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={1024-1034}
}
Increased expression of mac25/insulin-like growth factor binding-protein related protein-1 (IGFBP-rP1) in human breast and prostate epithelial cell lines results in the suppression of tumor growth. CDNA expression array analysis revealed increased manganese superoxide dismutase (SOD-2) expression in the mac25/IGFBP-rP1-transfected M12 human prostate cancer cell line compared to M12 control cells. SOD-2 has been postulated to be a tumor suppressor. SOD-2 was also increased in LNCaP cells stably… CONTINUE READING

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