Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging

@article{Sinha2014IncreasedMD,
  title={Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging},
  author={Jitendra Kumar Sinha and S. Ghosh and Umakanta Swain and N. V. Giridharan and Manchala Raghunath},
  journal={Neuroscience},
  year={2014},
  volume={269},
  pages={256-264}
}

Increased total DNA damage and oxidative stress in brain are associated with decreased longevity in high sucrose diet fed WNIN/Gr-Ob obese rats

The results suggest that HSD feeding decreased the longevity of WNIN/Gr-Ob obese rats probably by increasing oxidative stress and aggravating IR, a condition that precedes T2D.

High sucrose diet feeding aggravates age related changes in oxidative stress and antioxidant status of WNIN/Gr-Ob obese rats

Feeding HSD aggravated ageing associated systemic oxidative stress perhaps due to impaired anti oxidant status and may underlie the aggravated insulin resistance, which in turn accelerated their ageing.

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Epigenomic maintenance through dietary intervention can facilitate DNA repair process to slow down the progress of premature aging

It is proposed here that agents or interventions that can maintain epigenomic stability and facilitate the DNA repair process can slow down the progress of premature aging, if not completely prevent it.

The effects of delta‐9‐tetrahydrocannabinol on Krüppel‐like factor‐4 expression, redox homeostasis, and inflammation in the kidney of diabetic rat

According to the data, THC has ameliorative effects on the impaired redox status of diabetic kidney and also it acts as an immunomodulator.

Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity

It is demonstrated that WNIN is more prone to develop obesity and associated co-morbidities under high calorie environment, which underlines the cumulative role of genetics (nature) and diet (nurture) towards the development of obesity, which is critical for understanding this epidemic and devising new strategies to control and manage this modern malady.

Anthocyanins from Lycium ruthenicum Murr. Ameliorated d-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats.

Twelve anthocyanins from LR attenuated memory disfunction, neuroinflammation, and neurodegeneration caused by d-gal, possibly through the RAGE/NF-κB/JNK pathway, representing a promising, safe candidate for prevention and therapy of Neurodegenerative diseases.

New concepts to fight oxidative stress: nanosized three-dimensional supramolecular antioxidant assemblies

Three nanoscience-based 3D supramolecular assemblies, decorated with, or entrapping antioxidant compounds, or which possess intrinsic antioxidant activity are discussed and illustrated with recent examples to provide more efficient mitigation of oxidative stress.

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