Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging

@article{Sinha2014IncreasedMD,
  title={Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging},
  author={J. Sinha and S. Ghosh and U. Swain and N. Giridharan and M. Raghunath},
  journal={Neuroscience},
  year={2014},
  volume={269},
  pages={256-264}
}
  • J. Sinha, S. Ghosh, +2 authors M. Raghunath
  • Published 2014
  • Medicine, Biology
  • Neuroscience
  • Wistar of the National Institute of Nutrition obese (WNIN/Ob) is a unique rat strain isolated and established at NIN, Hyderabad, India, in 1996, from its existing stock of Wistar rat colony (WNIN). This animal model exhibits all traits of metabolic syndrome and has a remarkably reduced lifespan (1.5 years as compared to 3 years in parental WNIN rats), albeit, the factors associated with premature aging are not well understood. Considering that oxidative stress and DNA damage are crucial players… CONTINUE READING
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