Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging

  title={Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging},
  author={Jitendra Kumar Sinha and S. Ghosh and Umakanta Swain and N. V. Giridharan and Manchala Raghunath},

Increased total DNA damage and oxidative stress in brain are associated with decreased longevity in high sucrose diet fed WNIN/Gr-Ob obese rats

The results suggest that HSD feeding decreased the longevity of WNIN/Gr-Ob obese rats probably by increasing oxidative stress and aggravating IR, a condition that precedes T2D.

High sucrose diet feeding aggravates age related changes in oxidative stress and antioxidant status of WNIN/Gr-Ob obese rats

Feeding HSD aggravated ageing associated systemic oxidative stress perhaps due to impaired anti oxidant status and may underlie the aggravated insulin resistance, which in turn accelerated their ageing.

Increased stress and altered expression of histone modifying enzymes in brain are associated with aberrant behaviour in vitamin B12 deficient female mice

It is suggested that chronic vitamin B12 deficiency leads to behavioural anomalies in female C57BL/6 mice and the severity of these outcomes can be correlated to the level of deficiency.

Epigenomic maintenance through dietary intervention can facilitate DNA repair process to slow down the progress of premature aging

It is proposed here that agents or interventions that can maintain epigenomic stability and facilitate the DNA repair process can slow down the progress of premature aging, if not completely prevent it.

The effects of delta‐9‐tetrahydrocannabinol on Krüppel‐like factor‐4 expression, redox homeostasis, and inflammation in the kidney of diabetic rat

According to the data, THC has ameliorative effects on the impaired redox status of diabetic kidney and also it acts as an immunomodulator.

Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity

It is demonstrated that WNIN is more prone to develop obesity and associated co-morbidities under high calorie environment, which underlines the cumulative role of genetics (nature) and diet (nurture) towards the development of obesity, which is critical for understanding this epidemic and devising new strategies to control and manage this modern malady.

Anthocyanins from Lycium ruthenicum Murr. Ameliorated d-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats.

Twelve anthocyanins from LR attenuated memory disfunction, neuroinflammation, and neurodegeneration caused by d-gal, possibly through the RAGE/NF-κB/JNK pathway, representing a promising, safe candidate for prevention and therapy of Neurodegenerative diseases.

New concepts to fight oxidative stress: nanosized three-dimensional supramolecular antioxidant assemblies

Three nanoscience-based 3D supramolecular assemblies, decorated with, or entrapping antioxidant compounds, or which possess intrinsic antioxidant activity are discussed and illustrated with recent examples to provide more efficient mitigation of oxidative stress.



Protein and DNA oxidation in different anatomic regions of rat brain in a mimetic ageing model.

The results obtained from the mimetic ageing model rats showed that various anatomical regions of brain have different susceptibility to oxidative damage of proteins, lipids and DNA.

Oxidative damage increases with age in a canine model of human brain aging

Evidence of widespread oxidative damage and Aβ deposition is further justification for using the canine model for studying human brain aging and neurodegenerative diseases.

Effect of aging on brain-derived neurotrophic factor, proBDNF, and their receptors in the hippocampus of Lou/C rats.

Observations could account for the preserved cognitive performances and memory-dependent mechanisms, such as the unaltered long-term potentiation (LTP), throughout the lifespan recently reported in the Lou/C strain.

Oxidative stress in zinc-induced dopaminergic neurodegeneration: Implications of superoxide dismutase and heme oxygenase-1

The results obtained suggest that Zn-induced augmentation of total SOD, S OD1, SOD2 and HO-1 was associated with increased oxidative stress and neurodegenerative indexes indicating the involvement of both cytosolic and mitochondrial machinery in ZN-induced oxidative stress leading to dopaminergic Neurodegeneration.

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

The results are the first to show a significant decline in intracellular NAD+ levels and NAD∶NADH ratio in all organs by middle age compared to young rats, and suggest that adequate NAD+ concentrations may be an important longevity assurance factor.