Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging

@article{Sinha2014IncreasedMD,
  title={Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging},
  author={J. K. Sinha and S. Ghosh and U. Swain and N. Giridharan and M. Raghunath},
  journal={Neuroscience},
  year={2014},
  volume={269},
  pages={256-264}
}
Wistar of the National Institute of Nutrition obese (WNIN/Ob) is a unique rat strain isolated and established at NIN, Hyderabad, India, in 1996, from its existing stock of Wistar rat colony (WNIN). This animal model exhibits all traits of metabolic syndrome and has a remarkably reduced lifespan (1.5 years as compared to 3 years in parental WNIN rats), albeit, the factors associated with premature aging are not well understood. Considering that oxidative stress and DNA damage are crucial players… Expand
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References

SHOWING 1-10 OF 54 REFERENCES
Protein and DNA oxidation in different anatomic regions of rat brain in a mimetic ageing model.
TLDR
The results obtained from the mimetic ageing model rats showed that various anatomical regions of brain have different susceptibility to oxidative damage of proteins, lipids and DNA. Expand
Mitochondrial dysfunction in the hippocampus of rats caused by chronic oxidative stress
TLDR
Changes suggest that low doses of ozone caused mitochondrial abnormalities that may lead to cell damage and cellular damage, and mitochondrial swelling with a loss of mitochondrial cristae after 60 days of exposure. Expand
Long-term exercise treatment reduces oxidative stress in the hippocampus of aging rats
TLDR
The results suggest that long-term physical exercise can comprises antioxidant properties and by this way protect neurons against oxidative stress at the early stage of aging. Expand
Oxidative damage increases with age in a canine model of human brain aging
TLDR
Evidence of widespread oxidative damage and Aβ deposition is further justification for using the canine model for studying human brain aging and neurodegenerative diseases. Expand
Brain aging, memory impairment and oxidative stress: A study in Drosophila melanogaster
TLDR
It is demonstrated that a Drosophila long-lived strain, possessing enhanced activity of antioxidant enzymes and higher rate of resistance to oxidative stress, shows lower extent of AMI compared to normal lifespan strain. Expand
Lipid peroxidation in brain during aging in the senescence-accelerated mouse (SAM)
TLDR
The oldest age group contained the highest concentration of alpha-tocopherol, indicating a protection against oxidative damage of PUFA in brain membrane phospholipids. Expand
Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice
TLDR
A critical role for oxidative stress in age- related decline in learning and memory is confirmed and a potential usefulness for salen-manganese complexes in reversing age-related declines in cognitive function and oxidative load is suggested. Expand
Effect of aging on brain-derived neurotrophic factor, proBDNF, and their receptors in the hippocampus of Lou/C rats.
TLDR
Observations could account for the preserved cognitive performances and memory-dependent mechanisms, such as the unaltered long-term potentiation (LTP), throughout the lifespan recently reported in the Lou/C strain. Expand
Oxidative stress in zinc-induced dopaminergic neurodegeneration: Implications of superoxide dismutase and heme oxygenase-1
TLDR
The results obtained suggest that Zn-induced augmentation of total SOD, S OD1, SOD2 and HO-1 was associated with increased oxidative stress and neurodegenerative indexes indicating the involvement of both cytosolic and mitochondrial machinery in ZN-induced oxidative stress leading to dopaminergic Neurodegeneration. Expand
Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats
TLDR
The results are the first to show a significant decline in intracellular NAD+ levels and NAD:NADH ratio in all organs by middle age, and suggest that adequate NAD+ concentrations may be an important longevity assurance factor. Expand
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