Increased lymphocyte infiltration in patients with head and neck cancer treated with the IRX-2 immunotherapy regimen

@article{Berinstein2011IncreasedLI,
  title={Increased lymphocyte infiltration in patients with head and neck cancer treated with the IRX-2 immunotherapy regimen},
  author={Neil L. Berinstein and G T Wolf and Paul H. Naylor and Lorraine Baltzer and James E. Egan and Harvey J. Brandwein and Theresa L Whiteside and Lynn C. Goldstein and A El-naggar and C{\'e}cile Badoual and Wolf-Herv{\'e} Fridman and J Michael White and John W. Hadden},
  journal={Cancer Immunology, Immunotherapy},
  year={2011},
  volume={61},
  pages={771-782}
}
Twenty-seven subjects with squamous cell cancer of the head and neck received the neoadjuvant IRX-2 immunotherapy regimen prior to surgery in a Phase 2 trial. Pretreatment tumor biopsies were compared with the primary tumor surgical specimens for lymphocyte infiltration, necrosis and fibrosis, using hematoxylin and eosin stain and immunohistochemistry in 25 subjects. Sections were examined by three pathologists. Relative to pretreatment biopsies, increases in lymphocyte infiltration (LI) were… CONTINUE READING
Highly Cited
This paper has 23 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

a review

  • A Duray, S Demoulin, P Hubert, P Delvenne, head Saussez S. Immune suppression in, cancers neck
  • Clin Develop Immunology 2010; published on line…
  • 2012
3 Excerpts

A Phase 1 safety study of an IRX-2 regimen in subjects with squamous cell carcinoma of the head and neck

  • SM Freeman, JL Barrera, DE Kenady
  • Am J Clin Oncol
  • 2010
1 Excerpt

AACR meeting poster

  • B Schilling, M Harasymczuk, P Schuler
  • 2010
1 Excerpt

Increases prevalence of interleukin-17-producing CD4? tumor infiltrating lymphocytes in human oral squamous cell carcinoma

  • Lee J-J, Chang Y-L, Lai W-L
  • Head and Neck; published on line:
  • 2010
2 Excerpts

Similar Papers

Loading similar papers…