Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers.

@article{SnchezCspedes2001IncreasedLO,
  title={Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers.},
  author={Montserrat S{\'a}nchez-C{\'e}spedes and P. Anthony Decker and Kara M. Doffek and Manel Esteller and William H Westra and Eid Alawi and James G. Herman and Michael J. Demeure and David Sidransky and Steven Arthur Ahrendt},
  journal={Cancer research},
  year={2001},
  volume={61 5},
  pages={
          2092-6
        }
}
Epidemiological studies have demonstrated a causal association between tobacco use and carcinoma of the lung, and some genetic targets of the carcinogens in cigarette smoke have been defined recently. We further examined the effect of cigarette smoking on the frequency of allelic losses on chromosome 9p21 and the incidence of p16 inactivation. Chromosomal loss at 9p21-24 was determined by microsatellite analysis using 14 markers in 47 patients with non-small cell lung cancer. In addition, p16… CONTINUE READING

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